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DNMT3B decreases extracellular matrix degradation and alleviates intervertebral disc degeneration through TRPA1 methylation to inhibit the COX2/YAP axis
Intervertebral disc degeneration (IVDD) is a main cause of low back pain that is associated with extracellular matrix (ECM) degradation and inflammation. This study aims to investigate the role of DNMT3B and its regulatory mechanisms in IVDD. IVDD rat models were constructed followed by transfection...
Autores principales: | Luo, Zhiqiang, Ma, Yanchao, Di, Tianning, Ma, Bing, Li, Hongwei, An, Jiangdong, Wang, Yonggang, Zhang, Haihong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436916/ https://www.ncbi.nlm.nih.gov/pubmed/34428744 http://dx.doi.org/10.18632/aging.203410 |
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