Cancer-associated IDH mutations induce Glut1 expression and glucose metabolic disorders through a PI3K/Akt/mTORC1-Hif1α axis

Isocitrate dehydrogenase 1 and 2 (IDH1/2) mutations and their key effector 2-hydroxyglutarate (2-HG) have been reported to promote oncogenesis in various human cancers. To elucidate molecular mechanism(s) associated with IDH1/2 mutations, we established mouse embryonic fibroblasts (MEF) cells and hu...

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Detalles Bibliográficos
Autores principales: Liu, Xun, Yamaguchi, Kiyoshi, Takane, Kiyoko, Zhu, Chi, Hirata, Makoto, Hikiba, Yoko, Maeda, Shin, Furukawa, Yoichi, Ikenoue, Tsuneo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437293/
https://www.ncbi.nlm.nih.gov/pubmed/34516556
http://dx.doi.org/10.1371/journal.pone.0257090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437293/
https://www.ncbi.nlm.nih.gov/pubmed/34516556
http://dx.doi.org/10.1371/journal.pone.0257090

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