R-loops and regulatory changes in chronologically ageing fission yeast cells drive non-random patterns of genome rearrangements

Aberrant repair of DNA double-strand breaks can recombine distant chromosomal breakpoints. Chromosomal rearrangements compromise genome function and are a hallmark of ageing. Rearrangements are challenging to detect in non-dividing cell populations, because they reflect individually rare, heterogene...

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Detalles Bibliográficos
Autores principales: Ellis, David A., Reyes-Martín, Félix, Rodríguez-López, María, Cotobal, Cristina, Sun, Xi-Ming, Saintain, Quentin, Jeffares, Daniel C., Marguerat, Samuel, Tallada, Víctor A., Bähler, Jürg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437301/
https://www.ncbi.nlm.nih.gov/pubmed/34464389
http://dx.doi.org/10.1371/journal.pgen.1009784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437301/
https://www.ncbi.nlm.nih.gov/pubmed/34464389
http://dx.doi.org/10.1371/journal.pgen.1009784

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