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R-loops and regulatory changes in chronologically ageing fission yeast cells drive non-random patterns of genome rearrangements
Aberrant repair of DNA double-strand breaks can recombine distant chromosomal breakpoints. Chromosomal rearrangements compromise genome function and are a hallmark of ageing. Rearrangements are challenging to detect in non-dividing cell populations, because they reflect individually rare, heterogene...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437301/ https://www.ncbi.nlm.nih.gov/pubmed/34464389 http://dx.doi.org/10.1371/journal.pgen.1009784 |