The mechanism of MICU-dependent gating of the mitochondrial Ca(2+)uniporter

Ca(2+) entry into mitochondria is through the mitochondrial calcium uniporter complex (MCU(cx)), a Ca(2+)-selective channel composed of five subunit types. Two MCU(cx) subunits (MCU and EMRE) span the inner mitochondrial membrane, while three Ca(2+)-regulatory subunits (MICU1, MICU2, and MICU3) resi...

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Detalles Bibliográficos
Autores principales: Garg, Vivek, Suzuki, Junji, Paranjpe, Ishan, Unsulangi, Tiffany, Boyman, Liron, Milescu, Lorin S, Lederer, W Jonathan, Kirichok, Yuriy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437439/
https://www.ncbi.nlm.nih.gov/pubmed/34463251
http://dx.doi.org/10.7554/eLife.69312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437439/
https://www.ncbi.nlm.nih.gov/pubmed/34463251
http://dx.doi.org/10.7554/eLife.69312

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