Structure, dynamics, and regulation of TRF1-TIN2-mediated trans- and cis-interactions on telomeric DNA

TIN2 is a core component of the shelterin complex linking double-stranded telomeric DNA-binding proteins (TRF1 and TRF2) and single-strand overhang-binding proteins (TPP1-POT1). In vivo, the large majority of TRF1 and TRF2 exist in complexes containing TIN2 but lacking TPP1/POT1; however, the role o...

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Detalles Bibliográficos
Autores principales: Pan, Hai, Kaur, Parminder, Barnes, Ryan, Detwiler, Ariana C., Sanford, Samantha Lynn, Liu, Ming, Xu, Pengning, Mahn, Chelsea, Tang, Qingyu, Hao, Pengyu, Bhattaram, Dhruv, You, Changjiang, Gu, Xinyun, Lu, Warren, Piehler, Jacob, Xu, Guozhou, Weninger, Keith, Riehn, Robert, Opresko, Patricia L., Wang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437784/
https://www.ncbi.nlm.nih.gov/pubmed/34403696
http://dx.doi.org/10.1016/j.jbc.2021.101080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437784/
https://www.ncbi.nlm.nih.gov/pubmed/34403696
http://dx.doi.org/10.1016/j.jbc.2021.101080

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