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Distinct pro-inflammatory properties of myeloid cell–derived apolipoprotein E2 and E4 in atherosclerosis promotion

Polymorphisms in the apolipoprotein E (apoE) gene are risk factors for chronic inflammatory diseases including atherosclerosis. The gene product apoE is synthesized in many cell types and has both lipid transport–dependent and lipid transport–independent functions. Previous studies have shown that a...

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Detalles Bibliográficos
Autores principales: Igel, Emily, Haller, April, Wolfkiel, Patrick R., Orr-Asman, Melissa, Jaeschke, Anja, Hui, David Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437825/
https://www.ncbi.nlm.nih.gov/pubmed/34425108
http://dx.doi.org/10.1016/j.jbc.2021.101106