Physiological and Pathological Ageing of Astrocytes in the Human Brain

Ageing is the greatest risk factor for dementia, although physiological ageing by itself does not lead to cognitive decline. In addition to ageing, APOE ε4 is genetically the strongest risk factor for Alzheimer’s disease and is highly expressed in astrocytes. There are indications that human astrocy...

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Detalles Bibliográficos
Autores principales: Verkerke, Marloes, Hol, Elly M., Middeldorp, Jinte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437874/
https://www.ncbi.nlm.nih.gov/pubmed/33559106
http://dx.doi.org/10.1007/s11064-021-03256-7
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author Verkerke, Marloes
Hol, Elly M.
Middeldorp, Jinte
author_facet Verkerke, Marloes
Hol, Elly M.
Middeldorp, Jinte
author_sort Verkerke, Marloes
collection PubMed
description Ageing is the greatest risk factor for dementia, although physiological ageing by itself does not lead to cognitive decline. In addition to ageing, APOE ε4 is genetically the strongest risk factor for Alzheimer’s disease and is highly expressed in astrocytes. There are indications that human astrocytes change with age and upon expression of APOE4. As these glial cells maintain water and ion homeostasis in the brain and regulate neuronal transmission, it is likely that age- and APOE4-related changes in astrocytes have a major impact on brain functioning and play a role in age-related diseases. In this review, we will discuss the molecular and morphological changes of human astrocytes in ageing and the contribution of APOE4. We conclude this review with a discussion on technical issues, innovations, and future perspectives on how to gain more knowledge on astrocytes in the human ageing brain.
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spelling pubmed-84378742021-09-29 Physiological and Pathological Ageing of Astrocytes in the Human Brain Verkerke, Marloes Hol, Elly M. Middeldorp, Jinte Neurochem Res Original Paper Ageing is the greatest risk factor for dementia, although physiological ageing by itself does not lead to cognitive decline. In addition to ageing, APOE ε4 is genetically the strongest risk factor for Alzheimer’s disease and is highly expressed in astrocytes. There are indications that human astrocytes change with age and upon expression of APOE4. As these glial cells maintain water and ion homeostasis in the brain and regulate neuronal transmission, it is likely that age- and APOE4-related changes in astrocytes have a major impact on brain functioning and play a role in age-related diseases. In this review, we will discuss the molecular and morphological changes of human astrocytes in ageing and the contribution of APOE4. We conclude this review with a discussion on technical issues, innovations, and future perspectives on how to gain more knowledge on astrocytes in the human ageing brain. Springer US 2021-02-08 2021 /pmc/articles/PMC8437874/ /pubmed/33559106 http://dx.doi.org/10.1007/s11064-021-03256-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Verkerke, Marloes
Hol, Elly M.
Middeldorp, Jinte
Physiological and Pathological Ageing of Astrocytes in the Human Brain
title Physiological and Pathological Ageing of Astrocytes in the Human Brain
title_full Physiological and Pathological Ageing of Astrocytes in the Human Brain
title_fullStr Physiological and Pathological Ageing of Astrocytes in the Human Brain
title_full_unstemmed Physiological and Pathological Ageing of Astrocytes in the Human Brain
title_short Physiological and Pathological Ageing of Astrocytes in the Human Brain
title_sort physiological and pathological ageing of astrocytes in the human brain
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437874/
https://www.ncbi.nlm.nih.gov/pubmed/33559106
http://dx.doi.org/10.1007/s11064-021-03256-7
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