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IDH1 mutant glioma is preferentially sensitive to the HDAC inhibitor panobinostat
INTRODUCTION: A large subset of diffusely infiltrative gliomas contains a gain-of-function mutation in isocitrate dehydrogenase 1 or 2 (IDH1/2(mut)) which produces 2-hydroxglutarate, an inhibitor of α-ketoglutarate-dependent DNA demethylases, thereby inducing widespread DNA and histone methylation....
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer US
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437887/ https://www.ncbi.nlm.nih.gov/pubmed/34424450 http://dx.doi.org/10.1007/s11060-021-03829-0 |