Mechanistic insights into the Japanese encephalitis virus RNA dependent RNA polymerase protein inhibition by bioflavonoids from Azadirachta indica

Japanese encephalitis (JE) virus is a flavivirus causing encephalitis causing neurological damage. RNA-dependent-RNA-polymerase (RdRp) is responsible for genome replication making it excellent anti-viral target. In this study, the crystal structure of JE RdRp (jRdRp) and bioflavonoids reported in Az...

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Detalles Bibliográficos
Autores principales: Dwivedi, Vivek Dhar, Singh, Ankita, El-Kafraway, Sherif Aly, Alandijany, Thamir A., Faizo, Arwa A., Bajrai, Leena Hussein, Kamal, Mohammad Amjad, Azhar, Esam Ibraheem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437980/
https://www.ncbi.nlm.nih.gov/pubmed/34518560
http://dx.doi.org/10.1038/s41598-021-96917-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437980/
https://www.ncbi.nlm.nih.gov/pubmed/34518560
http://dx.doi.org/10.1038/s41598-021-96917-0

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