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CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression
Coordinated chromatin interactions between enhancers and promoters are critical for gene regulation. The architectural protein CTCF mediates chromatin looping and is enriched at the boundaries of topologically associating domains (TADs), which are sub-megabase chromatin structures. In vitro CTCF dep...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438036/ https://www.ncbi.nlm.nih.gov/pubmed/34518536 http://dx.doi.org/10.1038/s41467-021-25604-5 |