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In situ delivery of biobutyrate by probiotic Escherichia coli for cancer therapy
Butyrate has a bioactive function to reduce carcinogenesis. To achieve targeted cancer therapy, this study developed bacterial cancer therapy (BCT) with butyrate as a payload. By metabolic engineering, Escherichia coli Nissle 1917 (EcN) was reprogrammed to synthesize butyrate (referred to as biobuty...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438071/ https://www.ncbi.nlm.nih.gov/pubmed/34518590 http://dx.doi.org/10.1038/s41598-021-97457-3 |