Tumor NLRP3-Derived IL-1β Drives the IL-6/STAT3 Axis Resulting in Sustained MDSC-Mediated Immunosuppression

Tumors evade the immune system by inducing inflammation. In melanoma, tumor-derived IL-1β drives inflammation and the expansion of highly immunosuppressive myeloid-derived suppressor cells (MDSCs). Similar in many tumors, melanoma is also linked to the downstream IL‐6/STAT3 axis. In this study, we o...

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Detalles Bibliográficos
Autores principales: Tengesdal, Isak W., Dinarello, Alberto, Powers, Nicholas E., Burchill, Matthew A., Joosten, Leo A. B., Marchetti, Carlo, Dinarello, Charles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438323/
https://www.ncbi.nlm.nih.gov/pubmed/34531850
http://dx.doi.org/10.3389/fimmu.2021.661323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438323/
https://www.ncbi.nlm.nih.gov/pubmed/34531850
http://dx.doi.org/10.3389/fimmu.2021.661323

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