Sitagliptin Reduces Endothelial Dysfunction and Apoptosis Induced by High-Fat Diet and Palmitate in Thoracic Aortas and Endothelial Cells via ROS-ER Stress-CHOP Pathway

Macrovascular disease is tightly associated with obesity-induced metabolic syndrome. Sitagliptin (SIT), an orally stable selective inhibitor of Dipeptidyl peptidase-4 (DPP-4), has protective effects on endothelium. However, the mechanisms enabling SIT to exhibit resistance to diet-induced obesity (D...

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Detalles Bibliográficos
Autores principales: Cao, Qiongqiong, Xu, Dongmei, Chen, Yong, Long, Yueming, Dai, Fang, Gui, Li, Lu, Yunxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438525/
https://www.ncbi.nlm.nih.gov/pubmed/34531738
http://dx.doi.org/10.3389/fphar.2021.670389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438525/
https://www.ncbi.nlm.nih.gov/pubmed/34531738
http://dx.doi.org/10.3389/fphar.2021.670389

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