Vancomyxins: Vancomycin-Polymyxin Nonapeptide Conjugates That Retain Anti-Gram-Positive Activity with Enhanced Potency against Gram-Negative Strains

[Image: see text] Vancomycin functions by binding to lipid II, the penultimate bacterial cell wall building block used by both Gram-positive and Gram-negative species. However, vancomycin is generally only able to exert its antimicrobial effect against Gram-positive strains as it cannot pass the out...

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Detalles Bibliográficos
Autores principales: van Groesen, Emma, Slingerland, Cornelis J., Innocenti, Paolo, Mihajlovic, Milos, Masereeuw, Rosalinde, Martin, Nathaniel I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438664/
https://www.ncbi.nlm.nih.gov/pubmed/34387988
http://dx.doi.org/10.1021/acsinfecdis.1c00318

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438664/
https://www.ncbi.nlm.nih.gov/pubmed/34387988
http://dx.doi.org/10.1021/acsinfecdis.1c00318

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