Enantioselective vinylogous-Mukaiyama-type dearomatisation by anion-binding catalysis

The first enantioselective vinylogous Mukaiyama-type dearomatisation of heteroarenes under anion-binding catalysis is presented. A recyclable tetrakistriazole catalyst was used for the enantiocontrol of the remote vinylogous active position of silyl dienol ethers. This approach provided chiral heter...

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Autores principales: Kaur, Kirandeep, Humbrías-Martín, Jorge, Hoppmann, Leon, Fernández-Salas, Jose A., Daniliuc, Constantin G., Alemán, José, Mancheño, Olga García
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438702/
https://www.ncbi.nlm.nih.gov/pubmed/34519302
http://dx.doi.org/10.1039/d1cc03514b
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author Kaur, Kirandeep
Humbrías-Martín, Jorge
Hoppmann, Leon
Fernández-Salas, Jose A.
Daniliuc, Constantin G.
Alemán, José
Mancheño, Olga García
author_facet Kaur, Kirandeep
Humbrías-Martín, Jorge
Hoppmann, Leon
Fernández-Salas, Jose A.
Daniliuc, Constantin G.
Alemán, José
Mancheño, Olga García
author_sort Kaur, Kirandeep
collection PubMed
description The first enantioselective vinylogous Mukaiyama-type dearomatisation of heteroarenes under anion-binding catalysis is presented. A recyclable tetrakistriazole catalyst was used for the enantiocontrol of the remote vinylogous active position of silyl dienol ethers. This approach provided chiral heterocycles bearing α,β-unsaturated chains with complete regioselectivity and excellent enantioselectivities (up to 97.5 : 2.5 e.r.).
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spelling pubmed-84387022021-09-27 Enantioselective vinylogous-Mukaiyama-type dearomatisation by anion-binding catalysis Kaur, Kirandeep Humbrías-Martín, Jorge Hoppmann, Leon Fernández-Salas, Jose A. Daniliuc, Constantin G. Alemán, José Mancheño, Olga García Chem Commun (Camb) Chemistry The first enantioselective vinylogous Mukaiyama-type dearomatisation of heteroarenes under anion-binding catalysis is presented. A recyclable tetrakistriazole catalyst was used for the enantiocontrol of the remote vinylogous active position of silyl dienol ethers. This approach provided chiral heterocycles bearing α,β-unsaturated chains with complete regioselectivity and excellent enantioselectivities (up to 97.5 : 2.5 e.r.). The Royal Society of Chemistry 2021-08-20 /pmc/articles/PMC8438702/ /pubmed/34519302 http://dx.doi.org/10.1039/d1cc03514b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Kaur, Kirandeep
Humbrías-Martín, Jorge
Hoppmann, Leon
Fernández-Salas, Jose A.
Daniliuc, Constantin G.
Alemán, José
Mancheño, Olga García
Enantioselective vinylogous-Mukaiyama-type dearomatisation by anion-binding catalysis
title Enantioselective vinylogous-Mukaiyama-type dearomatisation by anion-binding catalysis
title_full Enantioselective vinylogous-Mukaiyama-type dearomatisation by anion-binding catalysis
title_fullStr Enantioselective vinylogous-Mukaiyama-type dearomatisation by anion-binding catalysis
title_full_unstemmed Enantioselective vinylogous-Mukaiyama-type dearomatisation by anion-binding catalysis
title_short Enantioselective vinylogous-Mukaiyama-type dearomatisation by anion-binding catalysis
title_sort enantioselective vinylogous-mukaiyama-type dearomatisation by anion-binding catalysis
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438702/
https://www.ncbi.nlm.nih.gov/pubmed/34519302
http://dx.doi.org/10.1039/d1cc03514b
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