Carcinogen-induced DNA structural distortion differences in the RAS gene isoforms; the importance of local sequence

BACKGROUND: Local sequence context is known to have an impact on the mutational pattern seen in cancer. The RAS genes and a smoking carcinogen, Benzo[a]pyrene diol epoxide (BPDE), have been utilised to explore these context effects. BPDE is known to form an adduct at the guanines in a number of RAS...

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Detalles Bibliográficos
Autores principales: Menzies, Georgina E., Prior, Ian A., Brancale, Andrea, Reed, Simon H., Lewis, Paul D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439098/
https://www.ncbi.nlm.nih.gov/pubmed/34521464
http://dx.doi.org/10.1186/s13065-021-00777-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439098/
https://www.ncbi.nlm.nih.gov/pubmed/34521464
http://dx.doi.org/10.1186/s13065-021-00777-8

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