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Carcinogen-induced DNA structural distortion differences in the RAS gene isoforms; the importance of local sequence
BACKGROUND: Local sequence context is known to have an impact on the mutational pattern seen in cancer. The RAS genes and a smoking carcinogen, Benzo[a]pyrene diol epoxide (BPDE), have been utilised to explore these context effects. BPDE is known to form an adduct at the guanines in a number of RAS...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439098/ https://www.ncbi.nlm.nih.gov/pubmed/34521464 http://dx.doi.org/10.1186/s13065-021-00777-8 |