New indolesulfonamide derivatives targeting the colchicine site of tubulin: synthesis, anti-tumour activity, structure–activity relationships, and molecular modelling

Searching for improved indolesulfonamides with higher polarities, 45 new analogues with modifications on the sulfonamide nitrogen, the methoxyaniline, and/or the indole 3-position were synthesised. They show submicromolar to nanomolar antiproliferative IC(50) values against four human tumour cell li...

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Detalles Bibliográficos
Autores principales: Vicente-Blázquez, Alba, González, Myriam, Medarde, Manuel, Mollinedo, Faustino, Peláez, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439230/
https://www.ncbi.nlm.nih.gov/pubmed/34514909
http://dx.doi.org/10.1080/14756366.2021.1975277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439230/
https://www.ncbi.nlm.nih.gov/pubmed/34514909
http://dx.doi.org/10.1080/14756366.2021.1975277

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