Cargando…

Edaravone prevents high glucose-induced injury in retinal Müller cells through thioredoxin1 and the PGC-1α/NRF1/TFAM pathway

CONTEXT: Oxidative injury in a high-glucose (HG) environment may be a mechanism of diabetic retinopathy (DR) and edaravone can protect retinal ganglion cells by scavenging ROS. OBJECTIVE: To explore the effect of edaravone on HG-induced injury. MATERIALS AND METHODS: First, Müller cells were culture...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yin, Juanping, Chen, Xinke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439237/ https://www.ncbi.nlm.nih.gov/pubmed/34506218 http://dx.doi.org/10.1080/13880209.2021.1972123

Ejemplares similares

PGC-1alpha downstream transcription factors NRF-1 and TFAM are genetic modifiers of Huntington disease
por: Taherzadeh-Fard, Elahe, et al.
Publicado: (2011)

Agrimol B inhibits colon carcinoma progression by blocking mitochondrial function through the PGC-1α/NRF1/TFAM signaling pathway
por: Xiang, Dongyang, et al.
Publicado: (2022)

Lipoxin A4 attenuated dexamethasone-induced muscle atrophy via activation of PGC-1α/Nrf2/TFAM pathway
por: Rizk, Fatma H., et al.
Publicado: (2022)

Expression of Mitochondrial Regulators PGC1α and TFAM as Putative Markers of Subtype and Chemoresistance in Epithelial Ovarian Carcinoma
por: Gabrielson, Marike, et al.
Publicado: (2014)

Testosterone Deficiency Caused by Castration Modulates Mitochondrial Biogenesis Through the AR/PGC1α/TFAM Pathway
por: Liu, Can, et al.
Publicado: (2019)

Thioredoxin-1 Promotes Mitochondrial Biogenesis Through Regulating AMPK/Sirt1/PGC1α Pathway in Alzheimer's Disease
por: Jia, Jinjing, et al.
Publicado: (2023)

Photobiomodulation promotes repair following spinal cord injury by restoring neuronal mitochondrial bioenergetics via AMPK/PGC-1α/TFAM pathway
por: Zhu, Zhijie, et al.
Publicado: (2022)

Heat shock protein 22 modulates NRF1/TFAM-dependent mitochondrial biogenesis and DRP1-sparked mitochondrial apoptosis through AMPK-PGC1α signaling pathway to alleviate the early brain injury of subarachnoid hemorrhage in rats
por: Fan, Haiyan, et al.
Publicado: (2021)

Astrocytes Protect Neurons from Aβ(1-42) Peptide-Induced Neurotoxicity Increasing TFAM and PGC-1 and Decreasing PPAR-γ and SIRT-1
por: Aguirre-Rueda, Diana, et al.
Publicado: (2015)

Huoxue Huatan Decoction Ameliorates Myocardial Ischemia/Reperfusion Injury in Hyperlipidemic Rats via PGC-1α–PPARα and PGC-1α–NRF1–mtTFA Pathways
por: Lin, Fei, et al.
Publicado: (2020)

SP-8356 (A Verbenone Derivative) Inhibits Proliferation, Suppresses Cell Migration and Invasion and Decreases Tumor Growth of Osteosarcoma: Role of PGC-1α/TFAM and AMPK-Activation
por: Cui, Wenning, et al.
Publicado: (2023)

Placental Mesenchymal Stem Cells Alleviate Podocyte Injury in Diabetic Kidney Disease by Modulating Mitophagy via the SIRT1-PGC-1alpha-TFAM Pathway
por: Han, Xiudan, et al.
Publicado: (2023)

Resveratrol Prevents ROS-Induced Apoptosis in High Glucose-Treated Retinal Capillary Endothelial Cells via the Activation of AMPK/Sirt1/PGC-1α Pathway
por: Li, Jun, et al.
Publicado: (2017)

High glucose concentrations induce oxidative stress by inhibiting Nrf2 expression in rat Müller retinal cells in vitro
por: Albert-Garay, Jesús Silvestre, et al.
Publicado: (2022)

Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration
por: Felszeghy, Szabolcs, et al.
Publicado: (2018)

Hepatic MicroRNA Expression by PGC-1α and PGC-1β in the Mouse
por: Piccinin, Elena, et al.
Publicado: (2019)

PGC-1α functions as a co-suppressor of XBP1s to regulate glucose metabolism
por: Lee, Jaemin, et al.
Publicado: (2017)

Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration
por: Rosales, Mariana Aparecida Brunini, et al.
Publicado: (2019)

PGC-1α–mediated angiogenesis prevents pulmonary hypertension in mice
por: Fujiwara, Takayuki, et al.
Publicado: (2023)

Protective effect of edaravone on blood-brain barrier by affecting NRF-2/HO-1 signaling pathway
por: Liu, Jing, et al.
Publicado: (2019)

Transcriptional Activity of PGC-1α and NT-PGC-1α Is Differentially Regulated by Twist-1 in Brown Fat Metabolism
por: Jun, Hee-Jin, et al.
Publicado: (2012)

A map of the PGC-1α- and NT-PGC-1α-regulated transcriptional network in brown adipose tissue
por: Chang, Ji Suk, et al.
Publicado: (2018)

PGC-1α Improves Glucose Homeostasis in Skeletal Muscle in an Activity-Dependent Manner
por: Summermatter, Serge, et al.
Publicado: (2013)

Insufficient sleep disrupts glucose metabolism during pregnancy by inhibiting PGC-1α
por: Wu, Hao, et al.
Publicado: (2022)

miR-373 Suppresses Cell Proliferation and Apoptosis via Regulation of SIRT1/PGC-1α/NRF2 Axis in Pancreatic Cancer
por: Yin, Qing-Hua, et al.
Publicado: (2021)

TFAM 1.0: an online tRNA function classifier
por: Tåquist, Helena, et al.
Publicado: (2007)

Edaravone Improves Septic Cardiac Function by Inducing an HIF-1α/HO-1 Pathway
por: He, Chao, et al.
Publicado: (2018)

Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway
por: Dang, Ruozhi, et al.
Publicado: (2022)

Comparison of Mitochondrial-Related Transcriptional Levels of TFAM, NRF1 and MT-CO1 Genes in Single Human Oocytes at Various Stages of the Oocyte Maturation
por: Ghaffari Novin, Marefat, et al.
Publicado: (2015)

Correction: Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration
por: Rosales, Mariana Aparecida Brunini, et al.
Publicado: (2019)

PGC1α: Friend or Foe in Cancer?
por: Mastropasqua, Francesca, et al.
Publicado: (2018)

Hyperhomocysteinemia-induced death of retinal ganglion cells: The role of Müller glial cells and NRF2
por: Navneet, Soumya, et al.
Publicado: (2019)

Simvastatin Impairs Glucose Homeostasis in Mice Depending on PGC-1α Skeletal Muscle Expression
por: Panajatovic, Miljenko Valentin, et al.
Publicado: (2020)

Upregulation of PGC-1α Attenuates Oxygen-Glucose Deprivation-Induced Hippocampal Neuronal Injury
por: Han, Bin, et al.
Publicado: (2022)

Acetylation and phosphorylation of human TFAM regulate TFAM–DNA interactions via contrasting mechanisms
por: King, Graeme A, et al.
Publicado: (2018)

Herba houttuyniae Extract Benefits Hyperlipidemic Mice via Activation of the AMPK/PGC-1α/Nrf2 Cascade
por: Cao, Ke, et al.
Publicado: (2020)

The Nrf2/PGC1α Pathway Regulates Antioxidant and Proteasomal Activity to Alter Cisplatin Sensitivity in Ovarian Cancer
por: Deng, Xinyue, et al.
Publicado: (2020)

The Protective Effects of Salidroside from Exhaustive Exercise-Induced Heart Injury by Enhancing the PGC-1 α–NRF1/NRF2 Pathway and Mitochondrial Respiratory Function in Rats
por: Ping, Zheng, et al.
Publicado: (2015)

Thioredoxin-Interacting Protein (TXNIP) Suppresses Expression of Glutamine Synthetase by Inducing Oxidative Stress in Retinal Muller Glia Under Diabetic Conditions
por: Zhou, Jia, et al.
Publicado: (2016)

PGC-1α and PGC-1β Increase Protein Synthesis via ERRα in C2C12 Myotubes
por: Brown, Erin L., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_4fta7tk7cvgkpu6jibm2cnl91p