Conformational Characterization of the Co-Activator Binding Site Revealed the Mechanism to Achieve the Bioactive State of FXR

FXR bioactive states are responsible for the regulation of metabolic pathways, which are modulated by agonists and co-activators. The synergy between agonist binding and ‘co-activator’ recruitment is highly conformationally driven. The characterization of conformational dynamics is essential for mec...

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Detalles Bibliográficos
Autores principales: Kumari, Anita, Mittal, Lovika, Srivastava, Mitul, Pathak, Dharam Pal, Asthana, Shailendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439381/
https://www.ncbi.nlm.nih.gov/pubmed/34532338
http://dx.doi.org/10.3389/fmolb.2021.658312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439381/
https://www.ncbi.nlm.nih.gov/pubmed/34532338
http://dx.doi.org/10.3389/fmolb.2021.658312

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