Cargando…
Analysis of amyloid-like secondary structure in the Cryab-R120G knock-in mouse model of hereditary cataracts by two-dimensional infrared spectroscopy
αB-crystallin is a small heat shock protein that forms a heterooligomeric complex with αA-crystallin in the ocular lens. It is also widely distributed in tissues throughout the body and has been linked with neurodegenerative diseases such as Alzheimer’s, where it is associated with amyloid fibrils....
Autores principales: | Alperstein, Ariel M., Molnar, Kathleen S., Dicke, Sidney S., Farrell, Kieran M., Makley, Leah N., Zanni, Martin T., Andley, Usha P. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439473/ https://www.ncbi.nlm.nih.gov/pubmed/34520490 http://dx.doi.org/10.1371/journal.pone.0257098 |
Ejemplares similares
-
Mechanism of Action of VP1-001 in cryAB(R120G)-Associated and Age-Related Cataracts
por: Molnar, Kathleen S., et al.
Publicado: (2019) -
A Knock-In Mouse Model for the R120G Mutation of αB-Crystallin Recapitulates Human Hereditary Myopathy and Cataracts
por: Andley, Usha P., et al.
Publicado: (2011) -
Missense Mutations in CRYAB Are Liable for Recessive Congenital Cataracts
por: Jiaox, Xiaodong, et al.
Publicado: (2015) -
Correction: Missense Mutations in CRYAB Are Liable for Recessive Congenital Cataracts
por: Jiao, Xiaodong, et al.
Publicado: (2017) -
Probing the changes in gene expression due to α-crystallin mutations in mouse models of hereditary human cataract
por: Andley, Usha P., et al.
Publicado: (2018)