Cargando…

Functional human genes typically exhibit epigenetic conservation

Recent DepMap CRISPR-Cas9 single gene disruptions have identified genes more essential to proliferation in tissue culture. It would be valuable to translate these finding with measurements more practical for human tissues. Here we show that DepMap essential genes and other literature curated functio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rud, Daniel, Marjoram, Paul, Siegmund, Kimberly, Shibata, Darryl
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439480/ https://www.ncbi.nlm.nih.gov/pubmed/34520456 http://dx.doi.org/10.1371/journal.pone.0253250

Ejemplares similares

Epigenetic Conservation Is a Beacon of Function: An Analysis Using Methcon5 Software for Studying Gene Methylation
por: Hvitfeldt, Emil, et al.
Publicado: (2020)

High DNA Methylation Pattern Intratumoral Diversity Implies Weak Selection in Many Human Colorectal Cancers
por: Siegmund, Kimberly D., et al.
Publicado: (2011)

Epigenetic Heterogeneity in Human Colorectal Tumors Reveals Preferential Conservation And Evidence of Immune Surveillance
por: Ryser, Marc D., et al.
Publicado: (2018)

Using DNA Methylation Patterns to Infer Tumor Ancestry
por: Hong, You Jin, et al.
Publicado: (2010)

Mutational signatures in colon cancer
por: Pandey, Priyatama, et al.
Publicado: (2019)

Early mutation bursts in colorectal tumors
por: Zhao, Junsong, et al.
Publicado: (2017)

HiLDA: a statistical approach to investigate differences in mutational signatures
por: Yang, Zhi, et al.
Publicado: (2019)

At least two well-spaced samples are needed to genotype a solid tumor
por: Siegmund, Kimberly, et al.
Publicado: (2016)

A Big Bang model of human colorectal tumor growth
por: Sottoriva, Andrea, et al.
Publicado: (2015)

Age-related human small intestine methylation: evidence for stem cell niches
por: Kim, Jung Yeon, et al.
Publicado: (2005)

iMutSig: a web application to identify the most similar mutational signature using shiny
por: Yang, Zhi, et al.
Publicado: (2020)

Cluster analysis for DNA methylation profiles having a detection threshold
por: Marjoram, Paul, et al.
Publicado: (2006)

Modeling measurement error in tumor characterization studies
por: Rakovski, Cyril, et al.
Publicado: (2011)

Epigenetic Subgroups of Esophageal and Gastric Adenocarcinoma with Differential GATA5 DNA Methylation Associated with Clinical and Lifestyle Factors
por: Wang, Xinhui, et al.
Publicado: (2011)

Epigenetic machinery is functionally conserved in cephalopods
por: Macchi, Filippo, et al.
Publicado: (2022)

Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation
por: Chambers, Stuart M, et al.
Publicado: (2007)

Definition, conservation and epigenetics of housekeeping and tissue-enriched genes
por: She, Xinwei, et al.
Publicado: (2009)

Conservation of social effects (Ψ) between two species of Drosophila despite reversal of sexual dimorphism
por: Signor, Sarah A., et al.
Publicado: (2017)

Epigenetic Pattern on the Human Y Chromosome Is Evolutionarily Conserved
por: Zhang, Minjie, et al.
Publicado: (2016)

Widespread Epigenetic Abnormalities Suggest a Broad DNA Methylation Erasure Defect in Abnormal Human Sperm
por: Houshdaran, Sahar, et al.
Publicado: (2007)

JMJD1C Exhibits Multiple Functions in Epigenetic Regulation during Spermatogenesis
por: Nakajima, Ryusuke, et al.
Publicado: (2016)

Diversity of Bacteria Exhibiting Bile Acid-inducible 7α-dehydroxylation Genes in the Human Gut
por: Vital, Marius, et al.
Publicado: (2019)

Copy number variation in the Framingham Heart Study
por: Shtir, Corina, et al.
Publicado: (2009)

The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease
por: Ma, Dingailu, et al.
Publicado: (2020)

Children with cerebral palsy exhibit greater and more regular postural sway than typically developing children
por: Donker, Stella F., et al.
Publicado: (2007)

VCP Associated Inclusion Body Myopathy and Paget Disease of Bone Knock-In Mouse Model Exhibits Tissue Pathology Typical of Human Disease
por: Badadani, Mallikarjun, et al.
Publicado: (2010)

Conservation of Aging and Cancer Epigenetic Signatures across Human and Mouse
por: Pérez, Raúl F, et al.
Publicado: (2021)

Specification and epigenomic resetting of the pig germline exhibit conservation with the human lineage
por: Zhu, Qifan, et al.
Publicado: (2021)

Study, conservation and exhibition of human remains: the need of a bioethical perspective
por: Licata, Marta, et al.
Publicado: (2020)

The Developing Human Connectome Project: typical and disrupted perinatal functional connectivity
por: Eyre, Michael, et al.
Publicado: (2021)

Lack of increases in methylation at three CpG-rich genomic loci in non-mitotic adult tissues during aging
por: Chu, Michelle W, et al.
Publicado: (2007)

Bayesian parameter estimation for automatic annotation of gene functions using observational data and phylogenetic trees
por: Vega Yon, George G., et al.
Publicado: (2021)

Environmental epigenetics: prospects for studying epigenetic mediation of exposure–response relationships
por: Cortessis, Victoria K., et al.
Publicado: (2012)

Metabolic Control of Epigenetics and Its Role in CD8(+) T Cell Differentiation and Function
por: Yerinde, Cansu, et al.
Publicado: (2019)

Conserved Epigenetic Regulatory Logic Infers Genes Governing Cell Identity
por: Shim, Woo Jun, et al.
Publicado: (2020)

In vitro CSC-derived cardiomyocytes exhibit the typical microRNA-mRNA blueprint of endogenous cardiomyocytes
por: Scalise, Mariangela, et al.
Publicado: (2021)

Epigenetic regulation of AXL and risk of childhood asthma symptoms
por: Gao, Lu, et al.
Publicado: (2017)

Primate protein-ligand interfaces exhibit significant conservation and unveil human-specific evolutionary drivers
por: King, Sean B., et al.
Publicado: (2023)

Design of typical genes for heterologous gene expression
por: Simm, Dominic, et al.
Publicado: (2022)

Transcription Factors Exhibit Differential Conservation in Bacteria with Reduced Genomes
por: Galán-Vásquez, Edgardo, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_sf01gecj87t15236efal3if7qi