Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace

The mTORC1 kinase complex regulates cell growth, proliferation, and survival. Because mis-regulation of DEPTOR, an endogenous mTORC1 inhibitor, is associated with some cancers, we reconstituted mTORC1 with DEPTOR to understand its function. We find that DEPTOR is a unique partial mTORC1 inhibitor th...

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Detalles Bibliográficos
Autores principales: Heimhalt, Maren, Berndt, Alex, Wagstaff, Jane, Anandapadamanaban, Madhanagopal, Perisic, Olga, Maslen, Sarah, McLaughlin, Stephen, Yu, Conny Wing-Heng, Masson, Glenn R, Boland, Andreas, Ni, Xiaodan, Yamashita, Keitaro, Murshudov, Garib N, Skehel, Mark, Freund, Stefan M, Williams, Roger L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439657/
https://www.ncbi.nlm.nih.gov/pubmed/34519269
http://dx.doi.org/10.7554/eLife.68799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439657/
https://www.ncbi.nlm.nih.gov/pubmed/34519269
http://dx.doi.org/10.7554/eLife.68799

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