Implementing Spanlastics for Improving the Ocular Delivery of Clotrimazole: In vitro Characterization, Ex vivo Permeability, Microbiological Assessment and In vivo Safety Study

PURPOSE: The aim of this study was to encapsulate clotrimazole (CLT), an antifungal drug with poor water solubility characteristics, into spanlastics (SPs) to provide a controlled ocular delivery of the drug. METHODS: Span 60 was used in the formulation of SPs with Tween 80, Pluronic F127, or Kollip...

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Detalles Bibliográficos
Autores principales: Abdelbari, Manar Adel, El-mancy, Shereen Sameh, Elshafeey, Ahmed Hassen, Abdelbary, Aly Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439980/
https://www.ncbi.nlm.nih.gov/pubmed/34531656
http://dx.doi.org/10.2147/IJN.S319348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439980/
https://www.ncbi.nlm.nih.gov/pubmed/34531656
http://dx.doi.org/10.2147/IJN.S319348

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