Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by hemizygosity of the psychiatric risk gene Cacna1c

Genetic variation in CACNA1C, which encodes the alpha-1 subunit of Ca(V)1.2 L-type voltage-gated calcium channels, is strongly linked to risk for psychiatric disorders including schizophrenia and bipolar disorder. To translate genetics to neurobiological mechanisms and rational therapeutic targets,...

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Detalles Bibliográficos
Autores principales: Tigaret, Cezar M., Lin, Tzu-Ching E., Morrell, Edward R., Sykes, Lucy, Moon, Anna L., O’Donovan, Michael C., Owen, Michael J., Wilkinson, Lawrence S., Jones, Matthew W., Thomas, Kerrie L., Hall, Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Immediate Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440217/
https://www.ncbi.nlm.nih.gov/pubmed/33597718
http://dx.doi.org/10.1038/s41380-020-01001-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440217/
https://www.ncbi.nlm.nih.gov/pubmed/33597718
http://dx.doi.org/10.1038/s41380-020-01001-0

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