Shikonin induces programmed death of fibroblast synovial cells in rheumatoid arthritis by inhibiting energy pathways

Shikonin is the main component of the traditional Chinese medicine comfrey, which can inhibit the activity of PKM2 by regulating glycolysis and ATP production. Rheumatoid arthritis synovial cells (RA-FLSs) have been reported to increase glycolytic activity and have other similar hallmarks of metabol...

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Detalles Bibliográficos
Autores principales: Li, Jiahui, Pang, Jinglong, Liu, Zhe, Ge, XianMing, Zhen, Yanan, Jiang, Chen Chen, Liu, Yaming, Huo, Qiang, Sun, Yiming, Liu, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440543/
https://www.ncbi.nlm.nih.gov/pubmed/34521930
http://dx.doi.org/10.1038/s41598-021-97713-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440543/
https://www.ncbi.nlm.nih.gov/pubmed/34521930
http://dx.doi.org/10.1038/s41598-021-97713-6

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