Carboplatin response in preclinical models for ovarian cancer: comparison of 2D monolayers, spheroids, ex vivo tumors and in vivo models

Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. Among the key challenges in developing effective therapeutics is the poor translation of preclinical models used in the drug discovery pipeline. This leaves drug attrition rates and costs at an unacceptably high level. Previous...

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Detalles Bibliográficos
Autores principales: Brodeur, Melica Nourmoussavi, Simeone, Kayla, Leclerc-Deslauniers, Kim, Fleury, Hubert, Carmona, Euridice, Provencher, Diane M., Mes-Masson, Anne-Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440566/
https://www.ncbi.nlm.nih.gov/pubmed/34521878
http://dx.doi.org/10.1038/s41598-021-97434-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440566/
https://www.ncbi.nlm.nih.gov/pubmed/34521878
http://dx.doi.org/10.1038/s41598-021-97434-w

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