Cargando…

Hypoxia increases KIAA1199/CEMIP expression and enhances cell migration in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is characterised by dense desmoplasia and hypoxic microenvironment. Our previous reports demonstrated that hyaluronan (HA), especially low-molecular-weight HA, provides a favourable microenvironment for PDAC progression. However, the effect of hypoxia on HA me...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oba, Takuya, Sato, Norihiro, Adachi, Yasuhiro, Amaike, Takao, Kudo, Yuzan, Koga, Atsuhiro, Kohi, Shiro, Hirata, Keiji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440617/ https://www.ncbi.nlm.nih.gov/pubmed/34521918 http://dx.doi.org/10.1038/s41598-021-97752-z

Ejemplares similares

KIAA1199 is induced by inflammation and enhances malignant phenotype in pancreatic cancer
por: Kohi, Shiro, et al.
Publicado: (2017)

Prognostic and functional role of hyaluronan-binding protein 1 in pancreatic ductal adenocarcinoma
por: Adachi, Yasuhiro, et al.
Publicado: (2022)

CEMIP (KIAA1199) induces a fibrosis-like process in osteoarthritic chondrocytes
por: Deroyer, Céline, et al.
Publicado: (2019)

CEMIP (KIAA1199) regulates inflammation, hyperplasia and fibrosis in osteoarthritis synovial membrane
por: Deroyer, Céline, et al.
Publicado: (2022)

Induction of KIAA1199/CEMIP is associated with colon cancer phenotype and poor patient survival
por: Fink, Stephen P., et al.
Publicado: (2015)

Hyaluronan activated-metabolism phenotype (HAMP) in pancreatic ductal adenocarcinoma
por: Kudo, Yuzan, et al.
Publicado: (2019)

Hyaluromycin, a Novel Hyaluronidase Inhibitor, Attenuates Pancreatic Cancer Cell Migration and Proliferation
por: Kohi, Shiro, et al.
Publicado: (2016)

Human TMEM2 is not a catalytic hyaluronidase, but a regulator of hyaluronan metabolism via HYBID (KIAA1199/CEMIP) and HAS2 expression
por: Sato, Shinya, et al.
Publicado: (2023)

Role of HYBID (Hyaluronan Binding Protein Involved in Hyaluronan Depolymerization), Alias KIAA1199/CEMIP, in Hyaluronan Degradation in Normal and Photoaged Skin
por: Yoshida, Hiroyuki, et al.
Publicado: (2019)

4-Methylumbelliferone inhibits enhanced hyaluronan synthesis and cell migration in pancreatic cancer cells in response to tumor-stromal interactions
por: Cheng, Xiao-Bo, et al.
Publicado: (2018)

Targeting hyaluronan for the treatment of pancreatic ductal adenocarcinoma
por: Sato, Norihiro, et al.
Publicado: (2016)

Hyaluronan stimulates pancreatic cancer cell motility
por: Cheng, Xiao-Bo, et al.
Publicado: (2015)

Receptor for Hyaluronic Acid-Mediated Motility is Associated with Poor Survival in Pancreatic Ductal Adenocarcinoma
por: Cheng, Xiao-Bo, et al.
Publicado: (2015)

An advanced bipolar device helps reduce the rate of postoperative pancreatic fistula in laparoscopic gastrectomy for gastric cancer patients: a propensity score-matched analysis
por: Shibao, Kazunori, et al.
Publicado: (2022)

Identification of KIAA1199 as a Biomarker for Pancreatic Intraepithelial Neoplasia
por: Suh, Han Na, et al.
Publicado: (2016)

Knockdown of KIAA1199 attenuates growth and metastasis of hepatocellular carcinoma
por: Liu, Jingmei, et al.
Publicado: (2018)

Triple bypass for advanced pancreatic head cancer associated with biliary stricture, duodenal stenosis, and recurrent obstructive pancreatitis
por: Kudo, Yuzan, et al.
Publicado: (2016)

KIAA1199 is a secreted molecule that enhances osteoblastic stem cell migration and recruitment
por: Chen, Li, et al.
Publicado: (2019)

Development of Therapeutic Agent for Osteoarthritis via Inhibition of KIAA1199 Activity: Effect of Ipriflavone In Vivo
por: Zhang, Jiarui, et al.
Publicado: (2023)

Murine homologue of the human KIAA1199 is implicated in hyaluronan binding and depolymerization()
por: Yoshida, Hiroyuki, et al.
Publicado: (2013)

KIAA1199 expression and hyaluronan degradation colocalize in multiple sclerosis lesions
por: Marella, Mathieu, et al.
Publicado: (2018)

Overexpression of KIAA1199, a novel strong hyaluronidase, is a poor prognostic factor in patients with osteosarcoma
por: Ito, Kan, et al.
Publicado: (2021)

Transcriptional and Epigenetic Regulation of KIAA1199 Gene Expression in Human Breast Cancer
por: Kuscu, Cem, et al.
Publicado: (2012)

KIAA1199 as a potential diagnostic biomarker of rheumatoid arthritis related to angiogenesis
por: Yang, Xinyu, et al.
Publicado: (2015)

Overexpression of KIAA1199 is an independent prognostic marker in laryngeal squamous cell carcinoma
por: Huang, Meixiang, et al.
Publicado: (2020)

Serum KIAA1199 is an advanced-stage prognostic biomarker and metastatic oncogene in cholangiocarcinoma
por: Zhai, Xiangyu, et al.
Publicado: (2020)

Co-expression of KIAA1199 and hypoxia-inducible factor 1α is a biomarker for an unfavorable prognosis in hepatocellular carcinoma
por: Wang, Dan, et al.
Publicado: (2020)

HIF1α/CCL7/KIAA1199 axis mediates hypoxia-induced gastric cancer aggravation and glycolysis alteration
por: Mi, Chen, et al.
Publicado: (2023)

Repression of KIAA1199 attenuates Wnt-signalling and decreases the proliferation of colon cancer cells
por: Birkenkamp-Demtroder, K, et al.
Publicado: (2011)

NF-κB-induced KIAA1199 promotes survival through EGFR signalling
por: Shostak, Kateryna, et al.
Publicado: (2014)

Distinct Expression Pattern of a Deafness Gene, KIAA1199, in a Primate Cochlea
por: Hosoya, Makoto, et al.
Publicado: (2016)

Role of hyaluronan in pancreatic cancer biology and therapy: Once again in the spotlight
por: Sato, Norihiro, et al.
Publicado: (2016)

Downregulation of KIAA1199 alleviated the activation, proliferation, and migration of hepatic stellate cells by the inhibition of epithelial–mesenchymal transition
por: Liu, Jingmei, et al.
Publicado: (2023)

Early Insights into the Function of KIAA1199, a Markedly Overexpressed Protein in Human Colorectal Tumors
por: Tiwari, Amit, et al.
Publicado: (2013)

Functional proteomic analysis reveals the involvement of KIAA1199 in breast cancer growth, motility and invasiveness
por: Jami, Mohammad-Saeid, et al.
Publicado: (2014)

Crohn’s Disease Fibroblasts Overproduce the Novel Protein KIAA1199 to Create Proinflammatory Hyaluronan Fragments
por: Soroosh, Artin, et al.
Publicado: (2016)

Downregulation of KIAA1199 by miR‐486‐5p suppresses tumorigenesis in lung cancer
por: Wang, Anqi, et al.
Publicado: (2020)

KIAA1199 deficiency enhances skeletal stem cell differentiation to osteoblasts and promotes bone regeneration
por: Chen, Li, et al.
Publicado: (2023)

KIAA1199 Correlates With Tumor Microenvironment and Immune Infiltration in Lung Adenocarcinoma as a Potential Prognostic Biomarker
por: Shen, Xiaoju, et al.
Publicado: (2022)

Possible Repositioning of an Oral Anti-Osteoporotic Drug, Ipriflavone, for Treatment of Inflammatory Arthritis via Inhibitory Activity of KIAA1199, a Novel Potent Hyaluronidase
por: Koike, Hiroshi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_plsjl13pkm1aki37u6qi84bnvo