Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains

Members of the LRRC8 family form heteromeric assemblies, which function as volume-regulated anion channels. These modular proteins consist of a transmembrane pore and cytoplasmic leucine-rich repeat (LRR) domains. Despite their known molecular architecture, the mechanism of activation and the role o...

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Detalles Bibliográficos
Autores principales: Deneka, Dawid, Rutz, Sonja, Hutter, Cedric A. J., Seeger, Markus A., Sawicka, Marta, Dutzler, Raimund
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440666/
https://www.ncbi.nlm.nih.gov/pubmed/34521847
http://dx.doi.org/10.1038/s41467-021-25742-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440666/
https://www.ncbi.nlm.nih.gov/pubmed/34521847
http://dx.doi.org/10.1038/s41467-021-25742-w

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