Direct interaction between ABCA1 and HIV-1 Nef: Molecular modeling and virtual screening for inhibitors

HIV-1 infection impairs cellular cholesterol efflux by downmodulating the cholesterol transporter ABCA1, leading to metabolic co-morbidities like cardio-vascular disease. The main mechanism of this effect is impairment by the HIV-1 protein Nef of the ABCA1 interaction with the endoplasmic reticulum...

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Detalles Bibliográficos
Autores principales: Adzhubei, Alexei A., Kulkarni, Amol, Tolstova, Anna P., Anashkina, Anastasia A., Sviridov, Dmitri, Makarov, Alexander A., Bukrinsky, Michael I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440812/
https://www.ncbi.nlm.nih.gov/pubmed/34584633
http://dx.doi.org/10.1016/j.csbj.2021.06.050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440812/
https://www.ncbi.nlm.nih.gov/pubmed/34584633
http://dx.doi.org/10.1016/j.csbj.2021.06.050

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