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Ligand Binding Introduces Significant Allosteric Shifts in the Locations of Protein Fluctuations
Allostery is usually considered to be a mechanism for transmission of signals associated with physical or dynamic changes in some part of a protein. Here, we investigate the changes in fluctuations across the protein upon ligand binding based on the fluctuations computed with elastic network models....
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440829/ https://www.ncbi.nlm.nih.gov/pubmed/34540902 http://dx.doi.org/10.3389/fmolb.2021.733148 |