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Physical and Functional Interaction of Mitochondrial Single-Stranded DNA-Binding Protein and the Catalytic Subunit of DNA Polymerase Gamma

The maintenance of the mitochondrial genome depends on a suite of nucleus-encoded proteins, among which the catalytic subunit of the mitochondrial replicative DNA polymerase, Pol γα, plays a pivotal role. Mutations in the Pol γα-encoding gene, POLG, are a major cause of human mitochondrial disorders...

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Detalles Bibliográficos
Autores principales: Ciesielski, Grzegorz L., Kim, Shalom, de Bovi Pontes, Carolina, Kaguni, Laurie S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440931/
https://www.ncbi.nlm.nih.gov/pubmed/34539752
http://dx.doi.org/10.3389/fgene.2021.721864