Cargando…

Sustained Baclofen-Induced Activation of GABA(B) Receptors After Cerebral Ischemia Restores Receptor Expression and Function and Limits Progressing Loss of Neurons

One important function of GABA(B) receptors is the control of neuronal activity to prevent overexcitation and thereby excitotoxic death, which is a hallmark of cerebral ischemia. Consequently, sustained activation of GABA(B) receptors with the selective agonist baclofen provides neuroprotection in i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hleihil, Mohammad, Vaas, Markus, Bhat, Musadiq A., Balakrishnan, Karthik, Benke, Dietmar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440977/ https://www.ncbi.nlm.nih.gov/pubmed/34539344 http://dx.doi.org/10.3389/fnmol.2021.726133

Ejemplares similares

Restoration of GABA(B) receptor expression in cerebral ischemia: a promising novel neuroprotective strategy
por: Bhat, Musadiq A., et al.
Publicado: (2023)

Targeting the interaction of GABA(B) receptors with CaMKII with an interfering peptide restores receptor expression after cerebral ischemia and inhibits progressive neuronal death in mouse brain cells and slices
por: Balakrishnan, Karthik, et al.
Publicado: (2022)

Protein phosphatase 2A regulation of GABA(B) receptors normalizes ischemia-induced aberrant receptor trafficking and provides neuroprotection
por: Hleihil, Mohammad, et al.
Publicado: (2022)

Targeting the Interaction of GABA(B) Receptors With CHOP After an Ischemic Insult Restores Receptor Expression and Inhibits Progressive Neuronal Death
por: Bhat, Musadiq A., et al.
Publicado: (2022)

ERK1/2-Dependent Phosphorylation of GABA(B1)(S867/T872), Controlled by CaMKIIβ, Is Required for GABA(B) Receptor Degradation under Physiological and Pathological Conditions
por: Bhat, Musadiq A., et al.
Publicado: (2023)

Ca(2+)/Calmodulin-Dependent Protein Kinase II (CaMKII) β-Dependent Phosphorylation of GABA(B1) Triggers Lysosomal Degradation of GABA(B) Receptors via Mind Bomb-2 (MIB2)-Mediated Lys-63-Linked Ubiquitination
por: Zemoura, Khaled, et al.
Publicado: (2018)

GABA(B) receptor agonist baclofen promotes central nervous system remyelination
por: Serrano‐Regal, Mari Paz, et al.
Publicado: (2022)

Antitussive effects of the peripherally restricted GABA(B) receptor agonist lesogaberan in guinea pigs: comparison to baclofen and other GABA(B) receptor-selective agonists
por: Canning, Brendan J, et al.
Publicado: (2012)

Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution
por: Duffet, Loïc, et al.
Publicado: (2023)

GABA(B)-Agonistic Activity of Certain Baclofen Homologues
por: Attia, Mohamed I., et al.
Publicado: (2013)

Using Baclofen to Explore GABA-B Receptor Function in Alcohol Dependence: Insights From Pharmacokinetic and Pharmacodynamic Measures
por: Durant, Claire F., et al.
Publicado: (2018)

Lys-63-linked Ubiquitination of γ-Aminobutyric Acid (GABA), Type B1, at Multiple Sites by the E3 Ligase Mind Bomb-2 Targets GABA(B) Receptors to Lysosomal Degradation
por: Zemoura, Khaled, et al.
Publicado: (2016)

Antinociceptive Effects of H(3) (R-Methylhistamine) and GABA(B) (Baclofen)-Receptor Ligands in an Orofacial Model of Pain in Rats
por: Nowak, Przemysław, et al.
Publicado: (2013)

GABA(B) Receptor Agonist R-Baclofen Reverses Altered Auditory Reactivity and Filtering in the Cntnap2 Knock-Out Rat
por: Möhrle, Dorit, et al.
Publicado: (2021)

Bidirectional regulation of distinct memory domains by α5-subunit-containing GABA(A) receptors in CA1 pyramidal neurons
por: Engin, Elif, et al.
Publicado: (2020)

Decreased GABA receptor in the cerebral cortex of epileptic rats: effect of Bacopa monnieri and Bacoside-A
por: Mathew, Jobin, et al.
Publicado: (2012)

Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABA(A) receptor subtype
por: Ralvenius, William T., et al.
Publicado: (2015)

GABA and the GABA(A) Receptor
por: Mihic, S. John, et al.
Publicado: (1997)

Influence of GABA-B Agonist Baclofen on Capsaicin-Induced Excitation of Secondary Peristalsis in Humans
por: Lei, Wei-Yi, et al.
Publicado: (2017)

The GABA receptors /
Publicado: (2007)

The gamma-aminobutyric acid type B (GABA(B)) receptor agonist baclofen inhibits morphine sensitization by decreasing the dopamine level in rat nucleus accumbens
por: Fu, Zhenyu, et al.
Publicado: (2012)

In vivo Imaging of Cannabinoid Type 2 Receptors: Functional and Structural Alterations in Mouse Model of Cerebral Ischemia by PET and MRI
por: Ni, Ruiqing, et al.
Publicado: (2021)

A single, clinically relevant dose of the GABA(B) agonist baclofen impairs visuomotor learning
por: Johnstone, Ainslie, et al.
Publicado: (2021)

Benefit of enteral baclofen in the management of spasticity in cerebral palsy
por: Srinivasan, Rajashree
Publicado: (2023)

Pharmacological chaperones restore proteostasis of epilepsy-associated GABA(A) receptor variants
por: Wang, Ya-Juan, et al.
Publicado: (2023)

Modulation of TLR3/TLR4 inflammatory signaling by the GABA(B) receptor agonist baclofen in glia and immune cells: relevance to therapeutic effects in multiple sclerosis
por: Crowley, Tadhg, et al.
Publicado: (2015)

GABA(B) receptor antagonist promotes hippocampal neurogenesis and facilitates cognitive function recovery following acute cerebral ischemia in mice
por: Song, Dan, et al.
Publicado: (2021)

Remodeling the endoplasmic reticulum proteostasis network restores proteostasis of pathogenic GABA(A) receptors
por: Fu, Yan-Lin, et al.
Publicado: (2018)

The Effect of Intrathecal Baclofen in Dyskinetic Cerebral Palsy: The IDYS Trial
por: Bonouvrié, Laura A., et al.
Publicado: (2019)

New GABA amides activating GABA(A)-receptors
por: Raster, Peter, et al.
Publicado: (2013)

Differential Ca(v)2.1 and Ca(v)2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABA(B) receptor activation
por: Berecki, Géza, et al.
Publicado: (2014)

A deeper insight into how GABA-B receptor agonism via baclofen may affect alcohol seeking and consumption: Lessons learned from a human laboratory investigation
por: Farokhnia, Mehdi, et al.
Publicado: (2018)

Endothelin Receptors, Mitochondria and Neurogenesis in Cerebral Ischemia
por: Gulati, Anil
Publicado: (2016)

Itch suppression in mice and dogs by modulation of spinal α2 and α3GABA(A) receptors
por: Ralvenius, William T., et al.
Publicado: (2018)

Antihyperalgesia by α2-GABA(A) Receptors Occurs Via a Genuine Spinal Action and Does Not Involve Supraspinal Sites
por: Paul, Jolly, et al.
Publicado: (2014)

A critical evaluation of oral baclofen in pediatric patients with cerebral palsy
por: McLaughlin, Matthew J., et al.
Publicado: (2023)

An Update on GABAρ Receptors
por: Martínez-Delgado, Gustavo, et al.
Publicado: (2010)

Electrophysiology of ionotropic GABA receptors
por: Sallard, Erwan, et al.
Publicado: (2021)

GABA receptor associated protein changes the electrostatic environment around the GABA type A receptor
por: Irwin, Benedict W. J., et al.
Publicado: (2021)

GABA(A)-Receptor Agonists Limit Pneumonitis and Death in Murine Coronavirus-Infected Mice
por: Tian, Jide, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_t7lp6pbc5u9bavprnn3nqv82gi