Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology

Aging, genomic stress, and mitochondrial dysfunction are risk factors for neurodegenerative pathologies, such as Parkinson disease (PD). Although genomic instability is associated with aging and mitochondrial impairment, the underlying mechanisms are poorly understood. Here, we show that base excisi...

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Detalles Bibliográficos
Autores principales: SenGupta, Tanima, Palikaras, Konstantinos, Esbensen, Ying Q., Konstantinidis, Georgios, Galindo, Francisco Jose Naranjo, Achanta, Kavya, Kassahun, Henok, Stavgiannoudaki, Ioanna, Bohr, Vilhelm A., Akbari, Mansour, Gaare, Johannes, Tzoulis, Charalampos, Tavernarakis, Nektarios, Nilsen, Hilde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441048/
https://www.ncbi.nlm.nih.gov/pubmed/34496255
http://dx.doi.org/10.1016/j.celrep.2021.109668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441048/
https://www.ncbi.nlm.nih.gov/pubmed/34496255
http://dx.doi.org/10.1016/j.celrep.2021.109668

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