A mechanism of cooling hot tumors: Lactate attenuates inflammation in dendritic cells

Turning non-inflamed (cold) tumors into inflamed (hot) tumors is important for maximizing the effect of immune checkpoint inhibitors (ICIs) against malignancies. We showed that lactate, a product of the Warburg effect, inhibited the efficacy of ICIs and suppressed IL-12 p40 expression in dendritic c...

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Detalles Bibliográficos
Autores principales: Kanemaru, Hisashi, Mizukami, Yukari, Kaneko, Akira, Tagawa, Hidemi, Kimura, Toshihiro, Kuriyama, Haruka, Sawamura, Soichiro, Kajihara, Ikko, Makino, Katsunari, Miyashita, Azusa, Aoi, Jun, Makino, Takamitsu, Masuguchi, Shinichi, Fukushima, Satoshi, Ihn, Hironobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441070/
https://www.ncbi.nlm.nih.gov/pubmed/34541473
http://dx.doi.org/10.1016/j.isci.2021.103067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441070/
https://www.ncbi.nlm.nih.gov/pubmed/34541473
http://dx.doi.org/10.1016/j.isci.2021.103067

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