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A mechanism of cooling hot tumors: Lactate attenuates inflammation in dendritic cells

Turning non-inflamed (cold) tumors into inflamed (hot) tumors is important for maximizing the effect of immune checkpoint inhibitors (ICIs) against malignancies. We showed that lactate, a product of the Warburg effect, inhibited the efficacy of ICIs and suppressed IL-12 p40 expression in dendritic c...

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Detalles Bibliográficos
Autores principales:	Kanemaru, Hisashi, Mizukami, Yukari, Kaneko, Akira, Tagawa, Hidemi, Kimura, Toshihiro, Kuriyama, Haruka, Sawamura, Soichiro, Kajihara, Ikko, Makino, Katsunari, Miyashita, Azusa, Aoi, Jun, Makino, Takamitsu, Masuguchi, Shinichi, Fukushima, Satoshi, Ihn, Hironobu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441070/ https://www.ncbi.nlm.nih.gov/pubmed/34541473 http://dx.doi.org/10.1016/j.isci.2021.103067

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