Cargando…

A mechanism of cooling hot tumors: Lactate attenuates inflammation in dendritic cells

Turning non-inflamed (cold) tumors into inflamed (hot) tumors is important for maximizing the effect of immune checkpoint inhibitors (ICIs) against malignancies. We showed that lactate, a product of the Warburg effect, inhibited the efficacy of ICIs and suppressed IL-12 p40 expression in dendritic c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kanemaru, Hisashi, Mizukami, Yukari, Kaneko, Akira, Tagawa, Hidemi, Kimura, Toshihiro, Kuriyama, Haruka, Sawamura, Soichiro, Kajihara, Ikko, Makino, Katsunari, Miyashita, Azusa, Aoi, Jun, Makino, Takamitsu, Masuguchi, Shinichi, Fukushima, Satoshi, Ihn, Hironobu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441070/ https://www.ncbi.nlm.nih.gov/pubmed/34541473 http://dx.doi.org/10.1016/j.isci.2021.103067

Ejemplares similares

Immunotherapy with 4-1BBL-Expressing iPS Cell‐Derived Myeloid Lines Amplifies Antigen-Specific T Cell Infiltration in Advanced Melanoma
por: Kuriyama, Haruka, et al.
Publicado: (2021)

Elevated Alpha 1(I) to Alpha 2(I) Collagen Ratio in Dermal Fibroblasts Possibly Contributes to Fibrosis in Systemic Sclerosis
por: Sawamura, Soichiro, et al.
Publicado: (2022)

Knockout of Endothelial Cell-Derived Endothelin-1 Attenuates Skin Fibrosis but Accelerates Cutaneous Wound Healing
por: Makino, Katsunari, et al.
Publicado: (2014)

A protocol for quantifying lymphocyte-mediated cytotoxicity using an impedance-based real-time cell analyzer
por: Kanemaru, Hisashi, et al.
Publicado: (2022)

Absence of microsatellite instability in extramammary Paget's disease
por: Kashiwada‐Nakamura, K., et al.
Publicado: (2021)

Investigation of FOXM1 as a Potential New Target for Melanoma
por: Miyashita, Azusa, et al.
Publicado: (2015)

Clinical Significance of Serum Vascular Endothelial-Cadherin Levels in Inflammatory Skin Diseases
por: Kuriyama, Haruka, et al.
Publicado: (2014)

Symptomless Pulmonary Cryptococcosis in a Psoriatic Arthritis Patient during Infliximab Therapy
por: Yamada, Saori, et al.
Publicado: (2016)

Chronic sun exposure-related fusion oncogenes EGFR-PPARGC1A in cutaneous squamous cell carcinoma
por: Egashira, Sho, et al.
Publicado: (2017)

Exome sequence analysis of Kaposiform hemangioendothelioma: identification of putative driver mutations
por: Egashira, Sho, et al.
Publicado: (2016)

Topical efinaconazole: A sequential combination therapy with oral terbinafine for refractory tinea unguium
por: Noguchi, Hiromitsu, et al.
Publicado: (2021)

Myasthenic crisis and polymyositis induced by one dose of nivolumab
por: Kimura, Toshihiro, et al.
Publicado: (2016)

Small bowel perforation due to indistinguishable metastasis of angiosarcoma: case report and brief literature review
por: Uchihara, Tomoyuki, et al.
Publicado: (2016)

Down-Regulation of mir-424 Contributes to the Abnormal Angiogenesis via MEK1 and Cyclin E1 in Senile Hemangioma: Its Implications to Therapy
por: Nakashima, Taiji, et al.
Publicado: (2010)

Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis
por: Higashi-Kuwata, Nobuyo, et al.
Publicado: (2010)

Circulating extracellular vesicle microRNAs associated with adverse reactions, proinflammatory cytokine, and antibody production after COVID-19 vaccination
por: Miyashita, Yusuke, et al.
Publicado: (2022)

Immune checkpoint inhibitors in the onset of myasthenia gravis with hyperCKemia
por: Takamatsu, Koutaro, et al.
Publicado: (2018)

Anti-connective tissue growth factor (CTGF/CCN2) monoclonal antibody attenuates skin fibrosis in mice models of systemic sclerosis
por: Makino, Katsunari, et al.
Publicado: (2017)

Non-small-cell Lung Cancer with Severe Skin Manifestations Related to Radiation Recall Dermatitis after Atezolizumab Treatment
por: Nakashima, Kei, et al.
Publicado: (2020)

Rare and Unusual Choroidal Abnormalities in a Patient with Systemic Lupus Erythematosus
por: Makino, Shinji, et al.
Publicado: (2013)

Changes in Optical Coherence Tomography Findings in Acute Zonal Occult Outer Retinopathy
por: Makino, Shinji, et al.
Publicado: (2013)

Ocular findings in two siblings with Joubert syndrome
por: Makino, Shinji, et al.
Publicado: (2014)

Acute Macular Neuroretinopathy in a 15-Year-Old Boy: Optical Coherence Tomography and Visual Acuity Findings
por: Makino, Shinji, et al.
Publicado: (2014)

Optical Coherence Tomography Imaging of Choroidal Abnormalities in Neurofibromatosis Type 1
por: Makino, Shinji, et al.
Publicado: (2013)

Characterization of Oligopeptides in Solanum lycopersicum Xylem Exudates
por: Okamoto, Satoru, et al.
Publicado: (2022)

Geographical Flushing of the Children's Face: A New Clinical Entity?
por: Jinnin, Masatoshi, et al.
Publicado: (2013)

Cooling Between Exercise Bouts and Post-exercise With the Fan Cooling Jacket on Thermal Strain in Hot-Humid Environments
por: Otani, Hidenori, et al.
Publicado: (2021)

Dual countertraction for extraction of abandoned leads with severe lead‐to‐lead adhesion
por: Toba, Masahiro, et al.
Publicado: (2021)

Interaction of gypsum and the rhizome of Anemarrhena asphodeloides plays an important role in anti-allergic effects of byakkokakeishito in mice
por: Makino, Toshiaki, et al.
Publicado: (2014)

Erythroplasia of Queyrat treated with imiquimod 5% cream: The necessity of regimen guidelines
por: Yokoyama, Maiko, et al.
Publicado: (2019)

Optical coherence tomography and fundus autofluorescence imaging study of chorioretinal atrophy involving the macula in Alagille syndrome
por: Makino, Shinji, et al.
Publicado: (2012)

An Optical Coherence Tomography and Fundus Autofluorescence Imaging Study of Peripapillary Acute Zonal Occult Outer Retinopathy
por: Makino, Shinji, et al.
Publicado: (2013)

Retinal Microvascular Abnormalities in Neurofibromatosis Type 1 Associated with Congenital Retinal Macrovessels
por: Makino, Shinji, et al.
Publicado: (2013)

Prepapillary Vascular Loop Associated with Persistent Hyperplastic Primary Vitreous
por: Makino, Shinji, et al.
Publicado: (2013)

An Unusual Presentation of Concurrent Congenital Grouped Pigmentation of the Retina with Albinotic Spots
por: Watanabe, Meri, et al.
Publicado: (2015)

Atypical Focal Choroidal Excavation with Macular Hole in a Patient with Alagille Syndrome
por: Misawa, Manami, et al.
Publicado: (2022)

High-resolution spectroscopy of buffer-gas-cooled phthalocyanine
por: Miyamoto, Yuki, et al.
Publicado: (2022)

Decreased levels of circulating CD34(+) cells are associated with coronary heart disease in Japanese patients with type 2 diabetes
por: Makino, Hisashi, et al.
Publicado: (2015)

Outcomes of surgical resection for gastric cancer liver metastases: a retrospective analysis
por: Kawahara, Kenji, et al.
Publicado: (2020)

In situ delivery of iPSC-derived dendritic cells with local radiotherapy generates systemic antitumor immunity and potentiates PD-L1 blockade in preclinical poorly immunogenic tumor models
por: Oba, Takaaki, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_atsjsirvvl7u8h156db79frneh