Mechanism and function of DNA replication‐independent DNA‐protein crosslink repair via the SUMO‐RNF4 pathway

DNA‐protein crosslinks (DPCs) obstruct essential DNA transactions, posing a serious threat to genome stability and functionality. DPCs are proteolytically processed in a ubiquitin‐ and DNA replication‐dependent manner by SPRTN and the proteasome but can also be resolved via targeted SUMOylation. How...

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Detalles Bibliográficos
Autores principales: Liu, Julio C Y, Kühbacher, Ulrike, Larsen, Nicolai B, Borgermann, Nikoline, Garvanska, Dimitriya H, Hendriks, Ivo A, Ackermann, Leena, Haahr, Peter, Gallina, Irene, Guérillon, Claire, Branigan, Emma, Hay, Ronald T, Azuma, Yoshiaki, Nielsen, Michael Lund, Duxin, Julien P, Mailand, Niels
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441304/
https://www.ncbi.nlm.nih.gov/pubmed/34346517
http://dx.doi.org/10.15252/embj.2020107413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441304/
https://www.ncbi.nlm.nih.gov/pubmed/34346517
http://dx.doi.org/10.15252/embj.2020107413

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