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Accurate prediction of B-form/A-form DNA conformation propensity from primary sequence: A machine learning and free energy handshake

DNA carries the genetic code of life, with different conformations associated with different biological functions. Predicting the conformation of DNA from its primary sequence, although desirable, is a challenging problem owing to the polymorphic nature of DNA. We have deployed a host of machine lea...

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Detalles Bibliográficos
Autores principales: Gupta, Abhijit, Kulkarni, Mandar, Mukherjee, Arnab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441556/
https://www.ncbi.nlm.nih.gov/pubmed/34553171
http://dx.doi.org/10.1016/j.patter.2021.100329