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Coarse-grained simulations uncover Gram-negative bacterial defense against polymyxins by the outer membrane

The outer membrane (OM) of Gram-negative bacteria is a formidable barrier against antibiotics. Understanding the structure and function of the OM is essential for the discovery of novel membrane-acting agents against multidrug-resistant Gram-negative pathogens. However, it remains challenging to obt...

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Detalles Bibliográficos
Autores principales: Jiang, Xukai, Sun, Yuliang, Yang, Kai, Yuan, Bing, Velkov, Tony, Wang, Lushan, Li, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441625/
https://www.ncbi.nlm.nih.gov/pubmed/34584634
http://dx.doi.org/10.1016/j.csbj.2021.06.051