Cargando…
Integrative Network-Based Analysis Reveals Gene Networks and Novel Drug Repositioning Candidates for Alzheimer Disease
BACKGROUND AND OBJECTIVES: To integrate genome-wide association study data with tissue-specific gene expression information to identify coexpression networks, biological pathways, and drug repositioning candidates for Alzheimer disease. METHODS: We integrated genome-wide association summary statisti...
Autores principales: | Gerring, Zachary F., Gamazon, Eric R., White, Anthony, Derks, Eske M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441674/ https://www.ncbi.nlm.nih.gov/pubmed/34532569 http://dx.doi.org/10.1212/NXG.0000000000000622 |
Ejemplares similares
-
A gene co-expression network-based analysis of multiple brain tissues reveals novel genes and molecular pathways underlying major depression
por: Gerring, Zachary F., et al.
Publicado: (2019) -
An analysis of genetically regulated gene expression across multiple tissues implicates novel gene candidates in Alzheimer’s disease
por: Gerring, Zachary F., et al.
Publicado: (2020) -
Using genetic drug-target networks to develop new drug hypotheses for major depressive disorder
por: Gaspar, Héléna A., et al.
Publicado: (2019) -
Drug repositioning in epilepsy reveals novel antiseizure candidates
por: Brueggeman, Leo, et al.
Publicado: (2018) -
Integrated transcriptomics reveals master regulators of lung adenocarcinoma and novel repositioning of drug candidates
por: De Bastiani, Marco Antônio, et al.
Publicado: (2019)