Micronuclei in Kif18a mutant mice form stable micronuclear envelopes and do not promote tumorigenesis

Micronuclei, whole or fragmented chromosomes spatially separated from the main nucleus, are associated with genomic instability and have been identified as drivers of tumorigenesis. Paradoxically, Kif18a mutant mice produce micronuclei due to asynchronous segregation of unaligned chromosomes in vivo...

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Detalles Bibliográficos
Autores principales: Sepaniac, Leslie A., Martin, Whitney, Dionne, Louise A., Stearns, Timothy M., Reinholdt, Laura G., Stumpff, Jason
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441830/
https://www.ncbi.nlm.nih.gov/pubmed/34515734
http://dx.doi.org/10.1083/jcb.202101165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441830/
https://www.ncbi.nlm.nih.gov/pubmed/34515734
http://dx.doi.org/10.1083/jcb.202101165

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