Radiolabeling and PET–MRI microdosing of the experimental cancer therapeutic, MN-anti-miR10b, demonstrates delivery to metastatic lesions in a murine model of metastatic breast cancer

BACKGROUND: In our earlier work, we identified microRNA-10b (miR10b) as a master regulator of the viability of metastatic tumor cells. This knowledge allowed us to design a miR10b-targeted therapeutic consisting of an anti-miR10b antagomir conjugated to ultrasmall iron oxide nanoparticles (MN), term...

Descripción completa

Detalles Bibliográficos
Autores principales: Le Fur, Mariane, Ross, Alana, Pantazopoulos, Pamela, Rotile, Nicholas, Zhou, Iris, Caravan, Peter, Medarova, Zdravka, Yoo, Byunghee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442631/
https://www.ncbi.nlm.nih.gov/pubmed/34531932
http://dx.doi.org/10.1186/s12645-021-00089-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442631/
https://www.ncbi.nlm.nih.gov/pubmed/34531932
http://dx.doi.org/10.1186/s12645-021-00089-5

Ejemplares similares