Improved broad-spectrum antibiotics against Gram-negative pathogens via darobactin biosynthetic pathway engineering

The development of new antibiotics is imperative to fight increasing mortality rates connected to infections caused by multidrug-resistant (MDR) bacteria. In this context, Gram-negative pathogens listed in the WHO priority list are particularly problematic. Darobactin is a ribosomally produced and p...

Descripción completa

Detalles Bibliográficos
Autores principales: Groß, Sebastian, Panter, Fabian, Pogorevc, Domen, Seyfert, Carsten E., Deckarm, Selina, Bader, Chantal D., Herrmann, Jennifer, Müller, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442675/
https://www.ncbi.nlm.nih.gov/pubmed/34659729
http://dx.doi.org/10.1039/d1sc02725e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442675/
https://www.ncbi.nlm.nih.gov/pubmed/34659729
http://dx.doi.org/10.1039/d1sc02725e

Ejemplares similares