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Improved broad-spectrum antibiotics against Gram-negative pathogens via darobactin biosynthetic pathway engineering

The development of new antibiotics is imperative to fight increasing mortality rates connected to infections caused by multidrug-resistant (MDR) bacteria. In this context, Gram-negative pathogens listed in the WHO priority list are particularly problematic. Darobactin is a ribosomally produced and p...

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Detalles Bibliográficos
Autores principales:	Groß, Sebastian, Panter, Fabian, Pogorevc, Domen, Seyfert, Carsten E., Deckarm, Selina, Bader, Chantal D., Herrmann, Jennifer, Müller, Rolf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442675/ https://www.ncbi.nlm.nih.gov/pubmed/34659729 http://dx.doi.org/10.1039/d1sc02725e

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