Borinostats: solid-phase synthesis of carborane-capped histone deacetylase inhibitors with a tailor-made selectivity profile

The elevated expression of histone deacetylases (HDACs) in various tumor types renders their inhibition an attractive strategy for epigenetic therapeutics. One key issue in the development of improved HDAC inhibitors (HDACis) is the selectivity for single HDAC isoforms over unspecific pan inhibition...

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Detalles Bibliográficos
Autores principales: Selg, Christoph, Schöler, Andrea, Schliehe-Diecks, Julian, Hanl, Maria, Sinatra, Laura, Borkhardt, Arndt, Sárosi, Menyhárt B., Bhatia, Sanil, Hey-Hawkins, Evamarie, Hansen, Finn K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442681/
https://www.ncbi.nlm.nih.gov/pubmed/34659728
http://dx.doi.org/10.1039/d1sc02268g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442681/
https://www.ncbi.nlm.nih.gov/pubmed/34659728
http://dx.doi.org/10.1039/d1sc02268g

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