A chemical biology approach reveals a dependency of glioblastoma on biotin distribution

Glioblastoma (GBM) is a uniformly lethal disease driven by glioma stem cells (GSCs). Here, we use a chemical biology approach to unveil previously unknown GBM dependencies. By studying sulconazole (SN) with anti-GSC properties, we find that SN disrupts biotin distribution to the carboxylases and his...

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ग्रंथसूची विवरण
मुख्य लेखकों: Yoon, Jeehyun, Grinchuk, Oleg V., Kannan, Srinivasaraghavan, Ang, Melgious Jin Yan, Li, Zhenglin, Tay, Emmy Xue Yun, Lok, Ker Zhing, Lee, Bernice Woon Li, Chuah, You Heng, Chia, Kimberly, Tirado Magallanes, Roberto, Liu, Chenfei, Zhao, Haonan, Hor, Jin Hui, Lim, Jhin Jieh, Benoukraf, Touati, Toh, Tan Boon, Chow, Edward Kai-Hua, Kovalik, Jean-Paul, Ching, Jianhong, Ng, Shi-Yan, Koh, Ming Joo, Liu, Xiaogang, Verma, Chandra Shekhar, Ong, Derrick Sek Tong
स्वरूप: Online लेख मूलपाठ
भाषा:English
प्रकाशित: American Association for the Advancement of Science 2021
विषय:
Biomedicine and Life Sciences
ऑनलाइन पहुंच:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442857/
https://www.ncbi.nlm.nih.gov/pubmed/34516894
http://dx.doi.org/10.1126/sciadv.abf6033

इंटरनेट

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442857/
https://www.ncbi.nlm.nih.gov/pubmed/34516894
http://dx.doi.org/10.1126/sciadv.abf6033

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