The anti-fibrotic drug pirfenidone inhibits liver fibrosis by targeting the small oxidoreductase glutaredoxin-1

Activation of the hepatic stellate cells (HSCs) is a key pathogenic event in liver fibrosis. Protein S-glutathionylation (PSSG) of cysteine residues is a distinct form of oxidative response that modifies protein structures and functions. Glutaredoxin-1 (GLRX) reverses PSSG by liberating glutathione...

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Detalles Bibliográficos
Autores principales: Xi, Yue, Li, Yanping, Xu, Pengfei, Li, Sihan, Liu, Zhengsheng, Tung, Hung-chun, Cai, Xinran, Wang, Jingyuan, Huang, Haozhe, Wang, Menglin, Xu, Meishu, Ren, Songrong, Li, Song, Zhang, Min, Lee, Yong J., Huang, Leaf, Yang, Da, He, Jinhan, Huang, Zhiying, Xie, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442864/
https://www.ncbi.nlm.nih.gov/pubmed/34516906
http://dx.doi.org/10.1126/sciadv.abg9241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442864/
https://www.ncbi.nlm.nih.gov/pubmed/34516906
http://dx.doi.org/10.1126/sciadv.abg9241

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