Ultrafast pore-loop dynamics in a AAA+ machine point to a Brownian-ratchet mechanism for protein translocation

AAA+ ring–shaped machines, such as the disaggregation machines ClpB and Hsp104, mediate ATP-driven substrate translocation through their central channel by a set of pore loops. Recent structural studies have suggested a universal hand-over-hand translocation mechanism with slow and rigid subunit mot...

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Detalles Bibliográficos
Autores principales: Mazal, Hisham, Iljina, Marija, Riven, Inbal, Haran, Gilad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Physical and Materials Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442866/
https://www.ncbi.nlm.nih.gov/pubmed/34516899
http://dx.doi.org/10.1126/sciadv.abg4674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442866/
https://www.ncbi.nlm.nih.gov/pubmed/34516899
http://dx.doi.org/10.1126/sciadv.abg4674

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