Rare genetic variability in human drug target genes modulates drug response and can guide precision medicine

Interindividual variability in drug response constitutes a major concern in pharmacotherapy. While polymorphisms in genes involved in drug disposition have been extensively studied, drug target variability remains underappreciated. By mapping the genomic variability of all human drug target genes on...

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Detalles Bibliográficos
Autores principales: Zhou, Yitian, Arribas, Gabriel Herras, Turku, Ainoleena, Jürgenson, Tuuli, Mkrtchian, Souren, Krebs, Kristi, Wang, Yi, Svobodova, Barbora, Milani, Lili, Schulte, Gunnar, Korabecny, Jan, Gastaldello, Stefano, Lauschke, Volker M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442892/
https://www.ncbi.nlm.nih.gov/pubmed/34516913
http://dx.doi.org/10.1126/sciadv.abi6856

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442892/
https://www.ncbi.nlm.nih.gov/pubmed/34516913
http://dx.doi.org/10.1126/sciadv.abi6856

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